Peripheral glucose homeostasis: does brain insulin matter?
نویسندگان
چکیده
منابع مشابه
Peripheral glucose homeostasis: does brain insulin matter?
Much controversy surrounds the relative role of insulin signaling in the brain in the control of hepatic glucose metabolism. In this issue of the JCI, Ramnanan and colleagues demonstrate that arterial infusion of insulin into the brains of dogs reduces net hepatic glucose output without altering endogenous glucose production. However, this effect was modest and required both prolonged fasting a...
متن کاملGlucose and Insulin Homeostasis in Ckd
S145 Cardiovascular disease (CVD) is the main cause of death in peritoneal dialysis (PD) patients, a situation that can be explained by a combination of traditional and nontraditional risk factors for CVD in these patients. Glucose and insulin homeostasis are altered in chronic kidney disease (CKD) patients even in the early stages of CKD, leading to insulin resistance by various pathways. Seve...
متن کاملBrain glucose sensing, counterregulation, and energy homeostasis.
Neuronal circuits in the central nervous system play a critical role in orchestrating the control of glucose and energy homeostasis. Glucose, beside being a nutrient, is also a signal detected by several glucose-sensing units that are located at different anatomical sites and converge to the hypothalamus to cooperate with leptin and insulin in controlling the melanocortin pathway.
متن کاملAcrylamide and glucose homeostasis Association Between Acrylamide, Blood Insulin and Insulin Resistance in Adults Running title: Acrylamide and glucose homeostasis
1, Department of Internal Medicine of Nephrology, En Chu Kong Hospital, Taipei County, Taiwan 2, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan 3, School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan 4, Department of Pediatrics, Taipei City Hospital, Zhongxiao Branch, Taipei, Taiwan 5, Department of...
متن کاملGut-brain mechanisms controlling glucose homeostasis
Our current understanding of glucose homeostasis is centered on glucose-induced secretion of insulin from pancreatic islets and insulin action on glucose metabolism in peripheral tissues. In addition, however, recent evidence suggests that neurocircuits located within a brain-centered glucoregulatory system work cooperatively with pancreatic islets to promote glucose homeostasis. Among key obse...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2011
ISSN: 0021-9738
DOI: 10.1172/jci59653